On 02 April 07 I posted an article in my block on “How to be Creative”. I discovered that somebody very kindly took out a statement I made and called it “Quote of the Day.”
The quote is “The greatness of a person can only emerge when he has shown his ability to create, passion to pursue, courage to commit and capability to achieve”.
His comments were: Two questions (may be four) that might follow from the quote,
1. Do I want to be great?
2. Do I agree? Does it really have to show? To whom?
MY REPLY:
It is part of human nature to want to be noticed for what one has done. This does not mean that everyone wants to be “great”. It is also a good practice for any individual or community to show appreciation to those who have contributed or done a good deed. This is part of our culture which we should retain. Much is being done at present in this direction. The question is can we do more? Do we always know how to do what has to be done and to whom. What criteria can we adopt without causing contradictions?
We know that “Some people are born great. Others have greatness thrust upon them.” My quotation describes those who have earned their “greatness” many of whom never worked for this status. These include national awards, professional recognition, community honours etc. In the past “great” men were only recognized posthumously. I like to suggest that more of our unsung heroes who have contributed in whatever field should be acknowledged while they are still alive. This will encourage more people to be creative and contribute for the betterment of our society.
Thanks for the comments.
Lee Kum Tatt
Monday, July 23, 2007
Thursday, July 19, 2007
The Days When Singapore Panicked - Part 2
Outbreak of Barley Poisoning
The Queenstown constituency where many deaths occurred had Dr. Lee Siew Choh as their Member of Parliament from the PAP party. Dr. Lee was also the Political Secretary of the Ministry of Health which my Department reported to. Naturally he and everybody else wanted to know who was really responsible and how to get compensation for the deaths of the eight children and the illness caused to the other people. I was again given the task of finding the answer with the Ministry’s backing.
Could the Parathion come from (i) spaying in the field or (ii) could it be a contamination from the ship’s hold on way to Singapore or (iii) contamination from the local shops. We examined several bags of barley and found that only those with a certain marking were found to be contaminated with the poison. Some were very badly soaked. Barley with different markings or from cans were not affected. Further investigation showed that this consignment came from a European cargo boat. With the cooperation of the local European Embassy we were informed that the particular cargo boat would be going to Miri, Sarawak, for fuel on a Saturday. I flew to Miri with the First Secretary of the European Embassy and waited for 10 days for the boat that never came. I was supposed to question the captain and examine the boat’s log books. Could the ship’s captain or owner have been tipped off ? This, we would never know.
When the boat did not turn up after five days I wanted to come home. My ministry did not allow this and I had to stay on until my personal funds were exhausted. That was 10 days in the one horse town of Miri. We showed that we did everything possible to find the ones responsible. The boat never turned up in Miri.
What were my feelings towards this case? I was happy that I rose to the occasion and had isolated and identified the poison so quickly. More important I confirmed that the killer was in the barley and it was the deadly insecticide Parathione which was prohibited for use in Singapore. My only regret was that we did not succeed in finding who was really responsible. At least we could then get some compensation for the bereaved families. Our consolation was that we did everything possible under the circumstances.
No doubt I am very proud of the way this case was handled. The tension was very great and I am glad I survived it all. It showed that with some common sense and a little courage to do something different, or even absurd, can help a lot. I must have smelled a lot of the fumes from the extracts and felt very dazed for a few days that followed. But I am satisfied I rose to the occasion. I learned how uneasy it was for the head that wore the crown. Yet someone has to wear it.
I am grateful my medical colleagues provided the help I needed. Under these circumstances I was able to do more than my normal duty. That was the satisfaction I had from this case. This taught me the need for good networking and that multidisciplinary approach is important to solving life’s problems. Any undue delay on my part would have caused many dearly. We had not only pinpointed the barley as the culprit but also identified the ‘Killer” insecticide. We managed to calm a panic stricken public in time and saved many traders thousands of dollars and possibly many lives. I had done my best and my only regret was that I could not help in finding the captain of the European cargo boat guilty of negligence. Otherwise at least the families of the deceased children would have got some form of compensation. I could not have solved this case without the help of so many people, particularly the police and my medical colleagues and my staff. These people are some of our unsung heroes and we have many of them to thank for solving this case so fast.
Recently we have SARS and bird flu for the past few years. We have yet to find a solution to solve these problems. This showed how serious some incidents can be. Luckily we managed to solve our “Barley Poisoning” outbreak in record time for which we are proud. The incident taught me that we must do everything possible to nip the problem in the bud. A lot depended on ourselves and our attitude towards the work to be done. We must be confident and not be afraid to try to do what we think is right. If we were not pro active and positive we might cause some very serious consequences to ourselves and to others in the process especially when one is professionally in charge of the project. I learned many lessons from this case which affected my life and the lives of many others, especially those who are doing research and have something to do with solving problems. I will share some of these lessons I learned in Part Three of this series and discussed how I did what I did.
Lee Kum Tatt
The Queenstown constituency where many deaths occurred had Dr. Lee Siew Choh as their Member of Parliament from the PAP party. Dr. Lee was also the Political Secretary of the Ministry of Health which my Department reported to. Naturally he and everybody else wanted to know who was really responsible and how to get compensation for the deaths of the eight children and the illness caused to the other people. I was again given the task of finding the answer with the Ministry’s backing.
Could the Parathion come from (i) spaying in the field or (ii) could it be a contamination from the ship’s hold on way to Singapore or (iii) contamination from the local shops. We examined several bags of barley and found that only those with a certain marking were found to be contaminated with the poison. Some were very badly soaked. Barley with different markings or from cans were not affected. Further investigation showed that this consignment came from a European cargo boat. With the cooperation of the local European Embassy we were informed that the particular cargo boat would be going to Miri, Sarawak, for fuel on a Saturday. I flew to Miri with the First Secretary of the European Embassy and waited for 10 days for the boat that never came. I was supposed to question the captain and examine the boat’s log books. Could the ship’s captain or owner have been tipped off ? This, we would never know.
When the boat did not turn up after five days I wanted to come home. My ministry did not allow this and I had to stay on until my personal funds were exhausted. That was 10 days in the one horse town of Miri. We showed that we did everything possible to find the ones responsible. The boat never turned up in Miri.
What were my feelings towards this case? I was happy that I rose to the occasion and had isolated and identified the poison so quickly. More important I confirmed that the killer was in the barley and it was the deadly insecticide Parathione which was prohibited for use in Singapore. My only regret was that we did not succeed in finding who was really responsible. At least we could then get some compensation for the bereaved families. Our consolation was that we did everything possible under the circumstances.
No doubt I am very proud of the way this case was handled. The tension was very great and I am glad I survived it all. It showed that with some common sense and a little courage to do something different, or even absurd, can help a lot. I must have smelled a lot of the fumes from the extracts and felt very dazed for a few days that followed. But I am satisfied I rose to the occasion. I learned how uneasy it was for the head that wore the crown. Yet someone has to wear it.
I am grateful my medical colleagues provided the help I needed. Under these circumstances I was able to do more than my normal duty. That was the satisfaction I had from this case. This taught me the need for good networking and that multidisciplinary approach is important to solving life’s problems. Any undue delay on my part would have caused many dearly. We had not only pinpointed the barley as the culprit but also identified the ‘Killer” insecticide. We managed to calm a panic stricken public in time and saved many traders thousands of dollars and possibly many lives. I had done my best and my only regret was that I could not help in finding the captain of the European cargo boat guilty of negligence. Otherwise at least the families of the deceased children would have got some form of compensation. I could not have solved this case without the help of so many people, particularly the police and my medical colleagues and my staff. These people are some of our unsung heroes and we have many of them to thank for solving this case so fast.
Recently we have SARS and bird flu for the past few years. We have yet to find a solution to solve these problems. This showed how serious some incidents can be. Luckily we managed to solve our “Barley Poisoning” outbreak in record time for which we are proud. The incident taught me that we must do everything possible to nip the problem in the bud. A lot depended on ourselves and our attitude towards the work to be done. We must be confident and not be afraid to try to do what we think is right. If we were not pro active and positive we might cause some very serious consequences to ourselves and to others in the process especially when one is professionally in charge of the project. I learned many lessons from this case which affected my life and the lives of many others, especially those who are doing research and have something to do with solving problems. I will share some of these lessons I learned in Part Three of this series and discussed how I did what I did.
Lee Kum Tatt
The Days When Singapore Panicked - Part 1
On the morning of Monday 7 September 1959 I found two excited police officers waiting for me in the Government Department of Chemistry where I worked. They informed me that there were eight deaths involving children and 31 others had been admitted to the General Hospital on Sunday 6 September 1959. The affected families were 22 from the Queenstown-Alexandra area, three from Victoria Street, 2 from Silat Road and one each from the old Kallang Airport area, Lavender Street, Geyland and Braddell Road. The territorial spread was quite wide. The children’s ages ranged from 4 months to 16 years old.
It was obvious the children must have taken some kind of poison or toxin, but nobody knew what these were or where they came from. Understandably the families were too distraught to say much to the police or the press. There was not much of a lead we could follow. I had to assume that the cause of death must have come from the food they took. I requested the police to find out what food they had taken and we would try to put the pieces together and start from there. Three families said that their children had taken some home made barley drinks besides other kinds of food. That was the only common lead we had to work on. Our job was to identify the source of poisoning as soon as possible to prevent further deaths. To be sure we must isolate and confirm the poison/s responsible. This was not easy under the circumstances. If it is botulism or toxin it is outside the scope of the chemists to detect these toxins. The other common poisonous chemicals like cyanides, arsenic, carbon monoxide or some alkaloids were not considered as likely candidates. Our only clue was that the children could have been killed by the barley drinks. Ridiculous and far fetch this suggestion might be we had to make some kind of statement to calm the public.
The ministries of Health and National Development were in constant contact with us throughout the day to find out whether we had found anything. I felt the pressure to get results. Unfortunately even my director could not give me any advice on what to do. I had to use my initiative and judgment on how best to proceed. I had a new chemist Mr. Theng Chye Yam and two laboratory assistants,the late Mr. Pwee Sai Cheow and Mr. Ng Hon Wing to assist in the extraction of the possible poison/s from the various types of food that the police had collected . We also had the stomachs of the deceased children and several stomach washouts from those who were still in hospital. I decided to work on some 15 samples of food rounded up from the families. By then it was already well passed lunch time. We informed the Ministries that barley appeared to be a possible source of poisoning although we did not know for sure how the poison could have been associated with such a common and harmless drink like barley. Under the circumstances the Government accepted our postulation (absurd as this may seem at the time) and issued a general statement warning the public to stay away from barley until the investigation was completed. Our responsibility was a heavy one. Under the circumstances we were expected to say something and we have to make a calculated guess. What if we were wrong? This was a terrible thought I dared not even entertain. I was a young chemist, my image could be affected and that of the new PAP self Government too. I realized that I had to pull out everything I had to provide the answers whatever happened. Many eyes were focused on me and I must not fail. Brave words but how was I to do what had to be done?
At that point in time I did not know how long it would take to pin point the source of poison and confirm what it was. I was not even certain that the poison/s could be found or be identified from the samples we had. Because of the announcement many who had taken some barley sought admissions into hospitals .They had their stomachs washout and we in the laboratory were flooded with such samples. Such panic response was not unexpected. They did not however help in our investigation.
Amidst this confusion and excitement I was at a loss of where to start and the pressure to produce results was very great. I knew that normal chemical investigation and identification of unknowns like this would take a long time. We may not even have any results at the end of it all. I went home that day at 10.00 pm , exhausted.
The nest day I decided to use white mice for the test on the 15 extracts where the poison could possibly be found. This was not a normal way a chemist work. I was never thought to be an orthodox person anyway. I had very few choices and the pressure to produce results was great. Professor Shumagaratnam of the Department of Pathology provided me with some white mice. I injected one mouse and it died instantly. Hurrah,! I exclaimed, only to be told that the mouse may have died due to trauma caused by me in injecting it. I then injected the extracts into numerous small pieces of cheese and fed them to the mice. It must have been common sense that made me do what I did. Luck was with me. After a few minutes one of the mice dropped dead. I repeated the experiment and obtained the same results on another mouse. Eureka, I shouted. The poison that killed the mice was from a barley extract.! We had not misled the Government, and the Government had not misled the people by their announcements. That released part of the pressure I had the day before.
I still did not know what to look for in that particular extract. I talked to the late Dr. Quah Quee Guan, Head of the East Pediatric Unit of the Singapore General Hospital (SGH).
She told me that certain muscular activities of the patients were affected which responded to atropine injections. This indicated that the poison, whatever it was, exhibited an anti-cholinesterase reaction to produce the observed symptoms.
It was already 7 pm on Tuesday 8th September 1959. . I was the only one left in the Department. I called the late Professor Robert Lin, Head of the Department of Pharmacology of the University. He was happy to assist me to check on anti-cholinesterase activity using a rabbit aorta, a standard experiment for medical students. By 9.00 pm we confirmed that the extract from the barely contained this poison which could have caused the death of the children.
What poison could this be ? I had to make a guess again. There were many possibilities. I chose to zero in on Florinated organo-phosphate insecticides. The insecticides, which Singapore imported in those days such as marathione, were not known to be that poisonous unless taken in large quantities. I decided to look for Parathione although I was not sure how this could have got into the barley. Furthermore Parathione was banned in Singapore then. Nevertheless I proceeded through the night and confirmed the presence of Parathione in the barley extracts by chemical methods on the morning of 9th September. An announcement was immediately made that the “killer’ has been found at 10.00 a.m. on Wednesday 9th September . The public anxiety which had been raised to a frenzy had at least been partially settled with this confirmation. I felt very good and much relieved but the stress and the fumes from parathione knocked me out for a few days after that.
I worked on the stomachs of the children, and confirmed the presence of Parathione .
After that I left the testing of the other extracts from the remaining food to Mr. Theng and my two other laboratory assistants. As I expected they got negative results from the more than 40 samples of other food taken from the families. This confirmed that we had not missed anything out.
After that the important issue to be settled quickly was how to control the barley containing the killer from being consumed and killing more people. Some suggested destroying all barley stock then available in Singapore. This was a panic measure which we advised against as it would cost the traders a lot of money. How then were we supposed to handle the situation? Who would be made responsible should we make a mistake? What if more people die? This was one time when I really felt the responsibility of my work and its pressure. We managed to solve it in record time by shear good luck and with the cooperation of some many kind people. I could not have solved the problem using pure chemistry alone. I learned many lessons from this experience and how to make my I.Q, E.Q. and A.Q. work together to achieve what we have to achieve.
The Government kept on announcing through the various media not to take barley until further investigations were completed. That was sufficient to stop people from buying and taking barley.
In the meanwhile working with the police, we rounded several samples of barley from shops in the affected areas. We noticed that only barley bearing certain markings on their gunny bags was found to contain the insecticide. Some bags were badly soaked with the insecticide. It was then obvious that only a certain batch of barley was the culprit. We recommended all remaining barley from that particular consignment be rounded up and destroyed. There was no resistance or negative response from the public on this issue.
What happened in Singapore also affected the Federation of Malaya. Several Federal Government health statements were reported by all State Health Departments. They also advised their public not to consume barley in any form until investigations are completed. Kuala Lumpur also reported 4 supposedly barley poison cases.
The question still remained to be answered was “ How did the poison get into the barley ?”
Who should be responsible for the deaths of our children? Please see Part Two on this series.
Lee Kum Tatt
It was obvious the children must have taken some kind of poison or toxin, but nobody knew what these were or where they came from. Understandably the families were too distraught to say much to the police or the press. There was not much of a lead we could follow. I had to assume that the cause of death must have come from the food they took. I requested the police to find out what food they had taken and we would try to put the pieces together and start from there. Three families said that their children had taken some home made barley drinks besides other kinds of food. That was the only common lead we had to work on. Our job was to identify the source of poisoning as soon as possible to prevent further deaths. To be sure we must isolate and confirm the poison/s responsible. This was not easy under the circumstances. If it is botulism or toxin it is outside the scope of the chemists to detect these toxins. The other common poisonous chemicals like cyanides, arsenic, carbon monoxide or some alkaloids were not considered as likely candidates. Our only clue was that the children could have been killed by the barley drinks. Ridiculous and far fetch this suggestion might be we had to make some kind of statement to calm the public.
The ministries of Health and National Development were in constant contact with us throughout the day to find out whether we had found anything. I felt the pressure to get results. Unfortunately even my director could not give me any advice on what to do. I had to use my initiative and judgment on how best to proceed. I had a new chemist Mr. Theng Chye Yam and two laboratory assistants,the late Mr. Pwee Sai Cheow and Mr. Ng Hon Wing to assist in the extraction of the possible poison/s from the various types of food that the police had collected . We also had the stomachs of the deceased children and several stomach washouts from those who were still in hospital. I decided to work on some 15 samples of food rounded up from the families. By then it was already well passed lunch time. We informed the Ministries that barley appeared to be a possible source of poisoning although we did not know for sure how the poison could have been associated with such a common and harmless drink like barley. Under the circumstances the Government accepted our postulation (absurd as this may seem at the time) and issued a general statement warning the public to stay away from barley until the investigation was completed. Our responsibility was a heavy one. Under the circumstances we were expected to say something and we have to make a calculated guess. What if we were wrong? This was a terrible thought I dared not even entertain. I was a young chemist, my image could be affected and that of the new PAP self Government too. I realized that I had to pull out everything I had to provide the answers whatever happened. Many eyes were focused on me and I must not fail. Brave words but how was I to do what had to be done?
At that point in time I did not know how long it would take to pin point the source of poison and confirm what it was. I was not even certain that the poison/s could be found or be identified from the samples we had. Because of the announcement many who had taken some barley sought admissions into hospitals .They had their stomachs washout and we in the laboratory were flooded with such samples. Such panic response was not unexpected. They did not however help in our investigation.
Amidst this confusion and excitement I was at a loss of where to start and the pressure to produce results was very great. I knew that normal chemical investigation and identification of unknowns like this would take a long time. We may not even have any results at the end of it all. I went home that day at 10.00 pm , exhausted.
The nest day I decided to use white mice for the test on the 15 extracts where the poison could possibly be found. This was not a normal way a chemist work. I was never thought to be an orthodox person anyway. I had very few choices and the pressure to produce results was great. Professor Shumagaratnam of the Department of Pathology provided me with some white mice. I injected one mouse and it died instantly. Hurrah,! I exclaimed, only to be told that the mouse may have died due to trauma caused by me in injecting it. I then injected the extracts into numerous small pieces of cheese and fed them to the mice. It must have been common sense that made me do what I did. Luck was with me. After a few minutes one of the mice dropped dead. I repeated the experiment and obtained the same results on another mouse. Eureka, I shouted. The poison that killed the mice was from a barley extract.! We had not misled the Government, and the Government had not misled the people by their announcements. That released part of the pressure I had the day before.
I still did not know what to look for in that particular extract. I talked to the late Dr. Quah Quee Guan, Head of the East Pediatric Unit of the Singapore General Hospital (SGH).
She told me that certain muscular activities of the patients were affected which responded to atropine injections. This indicated that the poison, whatever it was, exhibited an anti-cholinesterase reaction to produce the observed symptoms.
It was already 7 pm on Tuesday 8th September 1959. . I was the only one left in the Department. I called the late Professor Robert Lin, Head of the Department of Pharmacology of the University. He was happy to assist me to check on anti-cholinesterase activity using a rabbit aorta, a standard experiment for medical students. By 9.00 pm we confirmed that the extract from the barely contained this poison which could have caused the death of the children.
What poison could this be ? I had to make a guess again. There were many possibilities. I chose to zero in on Florinated organo-phosphate insecticides. The insecticides, which Singapore imported in those days such as marathione, were not known to be that poisonous unless taken in large quantities. I decided to look for Parathione although I was not sure how this could have got into the barley. Furthermore Parathione was banned in Singapore then. Nevertheless I proceeded through the night and confirmed the presence of Parathione in the barley extracts by chemical methods on the morning of 9th September. An announcement was immediately made that the “killer’ has been found at 10.00 a.m. on Wednesday 9th September . The public anxiety which had been raised to a frenzy had at least been partially settled with this confirmation. I felt very good and much relieved but the stress and the fumes from parathione knocked me out for a few days after that.
I worked on the stomachs of the children, and confirmed the presence of Parathione .
After that I left the testing of the other extracts from the remaining food to Mr. Theng and my two other laboratory assistants. As I expected they got negative results from the more than 40 samples of other food taken from the families. This confirmed that we had not missed anything out.
After that the important issue to be settled quickly was how to control the barley containing the killer from being consumed and killing more people. Some suggested destroying all barley stock then available in Singapore. This was a panic measure which we advised against as it would cost the traders a lot of money. How then were we supposed to handle the situation? Who would be made responsible should we make a mistake? What if more people die? This was one time when I really felt the responsibility of my work and its pressure. We managed to solve it in record time by shear good luck and with the cooperation of some many kind people. I could not have solved the problem using pure chemistry alone. I learned many lessons from this experience and how to make my I.Q, E.Q. and A.Q. work together to achieve what we have to achieve.
The Government kept on announcing through the various media not to take barley until further investigations were completed. That was sufficient to stop people from buying and taking barley.
In the meanwhile working with the police, we rounded several samples of barley from shops in the affected areas. We noticed that only barley bearing certain markings on their gunny bags was found to contain the insecticide. Some bags were badly soaked with the insecticide. It was then obvious that only a certain batch of barley was the culprit. We recommended all remaining barley from that particular consignment be rounded up and destroyed. There was no resistance or negative response from the public on this issue.
What happened in Singapore also affected the Federation of Malaya. Several Federal Government health statements were reported by all State Health Departments. They also advised their public not to consume barley in any form until investigations are completed. Kuala Lumpur also reported 4 supposedly barley poison cases.
The question still remained to be answered was “ How did the poison get into the barley ?”
Who should be responsible for the deaths of our children? Please see Part Two on this series.
Lee Kum Tatt
Wednesday, June 27, 2007
Classification of Research Activities
It is prestigious to be a research worker. Ask any research worker what they are doing and you will be surprised at the replies you receive. Some will tell you the high powered activities they are doing. Others will tell you how boring and even frustrating their work is. Ask the students whether they would be interested in doing research, the general reply is “it depends on what they are expected to do and the prospects.” People are generally not clear why they are doing their research and the prospects of the jobs. Happy are those who know what they are doing.
After years of involvement in the various types of research activities I have found the following definition and classification to be useful.
1. What is “Research”
2. Can it be classified so that the importance of the results can be rated.
True research is a quest driven by a specific question or problem which needs an answer or solution. Research activities are expected to answer questions of what, why and how. The first part answers the philosophical aspect of the question “what and why” are we doing the research for? Most of the famous wise men of ancient times are philosophers. They propounded theories e.g. the atomic, germ, gravity, electricity and many others and proved these theories are correct by further observations (experimental development or science). Even the “wise men” of modern times are known as doctors of Philosophy (Ph.D.).
The second part, the scientific aspect, is the more popular part nowadays. This part answers the questions of what and how the research results can and should be used to ensure that the activities will carry on.
For the purpose of this article we will confine ourselves to the scientific aspects of the questions and problems. The scientific and technological (S & T) activities can be divided into five categories namely:
* Basic or academic research
* Strategic research
* Mission oriented research
* Applied research or trouble shooting
* Routine work involving the use of some S & T knowledge
To understand what true research means to us we must know the reasons why we are doing what we are doing. Should there be more than one reason we must know the priorities and goals we set for ourselves. It can be tough to be faced with the problem of having to make money first instead of just producing the scientific results. It will take time to convert new knowledge into money. To be able to convert knowledge into funds is a specialty by itself. People who can produce research results and produce funds at the same time are difficult to find. These technopreneurs do not need us. We need them. This is one of our problems. However people like prospects and tenure in what they do. For a good researchers to be considered an authority in his field he needs continuity. This takes time to build and this often the main passion in their lives. How are they to get the support and funds they require? Are we promoting and providing enough funds to encourage research in our society for our own good?
I will confine Research as the creation of new science and technological (S & T) knowledge which can be used to confirm hypothesis or predictions that can be tested.
What are the main reasons for doing the various types of research?
a. Basic or academic research is the pursuit of knowledge for knowledge sake without any assumptions as to what the results may lead to. This type of research is usually done in universities whose functions include the generation of knowledge to teach the future generations. Funding such research depends on government policies.
b. Strategic research is the pursuit of new knowledge which might have practical application but without a precise view of the nature of the application or its timescale. This type of research involves big and forward looking organizations and even individuals to prepare themselves for the future. Such research can be risky but also can be very rewarding.
c. Mission orientated Research is knowledge specially developed with specific objectives in mind. These types of research usually involve and are funded by industries that like to convert new knowledge into products, process or technologies for their businesses.
d. Applied research or trouble shooting is a combination of existing knowledge required to solve an immediate problem in hand or to improve methods, processes and products. This type of research may be short lived but the results can be published in many scientific journals. Such research requires real knowledge and good skills to solve. The funding usually comes from the normal budget.
e. Routine work requiring S & T knowledge.
Some do not consider this type of work as research activities. Such activities do not require “specialists” or professionals to perform under the law, but skilled people are still required. Such work can throw up a lot of problems and potential projects that need to be solved.
Singapore has invested heavily in building a knowledge based industry. We have invested a lot in manpower and infrastructure development. The success of our effort in this exercise will depend on how well we can make use of our investment to deliver what we expected it to do. We have started some good research but much more needs to be done. How to assist those interested and ensure that they will not be unnecessarily hindered will continue to be our challenge. It will help to have some knowledge of the types of research we can and should do.
Basic or academic research and Strategic research do not produce results that can generate cash immediately. People find it easier to support Mission oriented and Applied research. We must widen the visions of some people so that more research can be done.
Lee Kum Tatt
After years of involvement in the various types of research activities I have found the following definition and classification to be useful.
1. What is “Research”
2. Can it be classified so that the importance of the results can be rated.
True research is a quest driven by a specific question or problem which needs an answer or solution. Research activities are expected to answer questions of what, why and how. The first part answers the philosophical aspect of the question “what and why” are we doing the research for? Most of the famous wise men of ancient times are philosophers. They propounded theories e.g. the atomic, germ, gravity, electricity and many others and proved these theories are correct by further observations (experimental development or science). Even the “wise men” of modern times are known as doctors of Philosophy (Ph.D.).
The second part, the scientific aspect, is the more popular part nowadays. This part answers the questions of what and how the research results can and should be used to ensure that the activities will carry on.
For the purpose of this article we will confine ourselves to the scientific aspects of the questions and problems. The scientific and technological (S & T) activities can be divided into five categories namely:
* Basic or academic research
* Strategic research
* Mission oriented research
* Applied research or trouble shooting
* Routine work involving the use of some S & T knowledge
To understand what true research means to us we must know the reasons why we are doing what we are doing. Should there be more than one reason we must know the priorities and goals we set for ourselves. It can be tough to be faced with the problem of having to make money first instead of just producing the scientific results. It will take time to convert new knowledge into money. To be able to convert knowledge into funds is a specialty by itself. People who can produce research results and produce funds at the same time are difficult to find. These technopreneurs do not need us. We need them. This is one of our problems. However people like prospects and tenure in what they do. For a good researchers to be considered an authority in his field he needs continuity. This takes time to build and this often the main passion in their lives. How are they to get the support and funds they require? Are we promoting and providing enough funds to encourage research in our society for our own good?
I will confine Research as the creation of new science and technological (S & T) knowledge which can be used to confirm hypothesis or predictions that can be tested.
What are the main reasons for doing the various types of research?
a. Basic or academic research is the pursuit of knowledge for knowledge sake without any assumptions as to what the results may lead to. This type of research is usually done in universities whose functions include the generation of knowledge to teach the future generations. Funding such research depends on government policies.
b. Strategic research is the pursuit of new knowledge which might have practical application but without a precise view of the nature of the application or its timescale. This type of research involves big and forward looking organizations and even individuals to prepare themselves for the future. Such research can be risky but also can be very rewarding.
c. Mission orientated Research is knowledge specially developed with specific objectives in mind. These types of research usually involve and are funded by industries that like to convert new knowledge into products, process or technologies for their businesses.
d. Applied research or trouble shooting is a combination of existing knowledge required to solve an immediate problem in hand or to improve methods, processes and products. This type of research may be short lived but the results can be published in many scientific journals. Such research requires real knowledge and good skills to solve. The funding usually comes from the normal budget.
e. Routine work requiring S & T knowledge.
Some do not consider this type of work as research activities. Such activities do not require “specialists” or professionals to perform under the law, but skilled people are still required. Such work can throw up a lot of problems and potential projects that need to be solved.
Singapore has invested heavily in building a knowledge based industry. We have invested a lot in manpower and infrastructure development. The success of our effort in this exercise will depend on how well we can make use of our investment to deliver what we expected it to do. We have started some good research but much more needs to be done. How to assist those interested and ensure that they will not be unnecessarily hindered will continue to be our challenge. It will help to have some knowledge of the types of research we can and should do.
Basic or academic research and Strategic research do not produce results that can generate cash immediately. People find it easier to support Mission oriented and Applied research. We must widen the visions of some people so that more research can be done.
Lee Kum Tatt
Thursday, June 21, 2007
What is research?
What is Research
How is it initiated and managed
This is a hot subject particularly among the students, researchers, public and private people and organizations that have to be involved, find the funds and manage these activities.
There is no accepted definition of what constitutes Research. There are many books and theses written on this subject. The term “Research” has caused a lot of confusion and controversies to students, researchers and people in general. My own idea of what research is, changed with time and experience over the last 55 years. In the process I have made my own definitions of Research to guide me and give me the focus I needed to handle Research as my profession and career. This helped me to compare apples with apples and pears with pears.
What I am going to say on Research is based on my experience as :
* a Ph.D. student
* a Chemist doing routine work and trouble shooting
* Head of Department with responsibilities to provide medical laboratory services to our hospitals.
* Chairman and CEO of SISIR helping our industries grow through provisions of S & T (scientific and technological) and R & D (research and development) services.
* Chairman and CEO of Singapore Science Council to promote R & D activities and S & T manpower development.
* Chairman of private companies where research is required to expand and stay relevant and competitive.
* As an individual working on projects of personal interests.
I have produced a simple chart based on my definition of Research and my classification of the types of research we can do. This has helped me in my work. This chart will be given in the coming articles. With the examples I am going to give it is hoped that some people will find the information useful. Research always starts through a question or problem. How some of the projects were initiated, implemented and managed differ from case to case. These are information many have asked me for many times in my life.
Lee Kum Tatt
How is it initiated and managed
This is a hot subject particularly among the students, researchers, public and private people and organizations that have to be involved, find the funds and manage these activities.
There is no accepted definition of what constitutes Research. There are many books and theses written on this subject. The term “Research” has caused a lot of confusion and controversies to students, researchers and people in general. My own idea of what research is, changed with time and experience over the last 55 years. In the process I have made my own definitions of Research to guide me and give me the focus I needed to handle Research as my profession and career. This helped me to compare apples with apples and pears with pears.
What I am going to say on Research is based on my experience as :
* a Ph.D. student
* a Chemist doing routine work and trouble shooting
* Head of Department with responsibilities to provide medical laboratory services to our hospitals.
* Chairman and CEO of SISIR helping our industries grow through provisions of S & T (scientific and technological) and R & D (research and development) services.
* Chairman and CEO of Singapore Science Council to promote R & D activities and S & T manpower development.
* Chairman of private companies where research is required to expand and stay relevant and competitive.
* As an individual working on projects of personal interests.
I have produced a simple chart based on my definition of Research and my classification of the types of research we can do. This has helped me in my work. This chart will be given in the coming articles. With the examples I am going to give it is hoped that some people will find the information useful. Research always starts through a question or problem. How some of the projects were initiated, implemented and managed differ from case to case. These are information many have asked me for many times in my life.
Lee Kum Tatt
Tuesday, June 19, 2007
Research & Managing Research - reply
QUESTION:
Could you talk about the difference between doing research and managing research ?
REPLY:
The question you raised cannot be answered without defining
a. what research means to you and the objectives of the projects you are involved in.
b. your personal position in the project and how much is your personal involvement.
Are you just a scientifically qualified individual given an assignment, a member of a research team, leader of a research team, head of an organization that needs to do research, head of an institution responsible for promoting and funding research without being personally involved in the nitty gritty of the research activities.
What you have to do depends on where you stand. I have held and experienced most of the positions described above, starting as
1. a research student,
2. a staff doing routine work and trouble shooting,
3 a head of department with its responsibilities to provide services to our hospitals
4. Chairman of SISIR helping Singapore to develop through its industries,
5. Founder Chairman of Singapore Science Council to promote R & D activities and
S & T manpower development.
6. CEO of companies where research is required to expand or stay relevant.
7. As an individual working on projects of personal interest.
Research has given me lots of joy but also not without some pain. I like to encourage people to do research and share with them what can be in store for them. I have tasted some of the “pies in the sky”. They are nice and enjoyable rewards but the ride to get there can be bumpy. Research can give many of us lots of pleasure and joy. However it is not the “koh yeoh” ( Chinese herbal medicinal plaster) that some people try to sell as something that can heal all ills. Some of the passed and the coming articles in my blog are written to encourage more people to do research in spite of the difficulties. This is what we need for Singapore. Take them for whatever they are worth to you.
Lee Kum Tatt
Could you talk about the difference between doing research and managing research ?
REPLY:
The question you raised cannot be answered without defining
a. what research means to you and the objectives of the projects you are involved in.
b. your personal position in the project and how much is your personal involvement.
Are you just a scientifically qualified individual given an assignment, a member of a research team, leader of a research team, head of an organization that needs to do research, head of an institution responsible for promoting and funding research without being personally involved in the nitty gritty of the research activities.
What you have to do depends on where you stand. I have held and experienced most of the positions described above, starting as
1. a research student,
2. a staff doing routine work and trouble shooting,
3 a head of department with its responsibilities to provide services to our hospitals
4. Chairman of SISIR helping Singapore to develop through its industries,
5. Founder Chairman of Singapore Science Council to promote R & D activities and
S & T manpower development.
6. CEO of companies where research is required to expand or stay relevant.
7. As an individual working on projects of personal interest.
Research has given me lots of joy but also not without some pain. I like to encourage people to do research and share with them what can be in store for them. I have tasted some of the “pies in the sky”. They are nice and enjoyable rewards but the ride to get there can be bumpy. Research can give many of us lots of pleasure and joy. However it is not the “koh yeoh” ( Chinese herbal medicinal plaster) that some people try to sell as something that can heal all ills. Some of the passed and the coming articles in my blog are written to encourage more people to do research in spite of the difficulties. This is what we need for Singapore. Take them for whatever they are worth to you.
Lee Kum Tatt
Quantitive Determination - reply
COMMENT:
I do not know too much about QA techniques used here but was there any problem with usuing ETDA chelation + UV-vis spectrophotometry of some sorts? Or were the amounts too small even for that ?
REPLY:
The incident I referred too happened in 1954. The technology was not as sophisticated then as it is now with modern instrumentation. The problem consisted of three parts:
a. the separation of Lead and Copper ions from the unholy organic mixtures in wine and the high sugar content in it for analysis.
b. the quantitative determination of these elements is from 0 to 1.5 parts per million in wine..
c. the strong urge to do something to improve the method then in use and face the consequences to make the change.
The first part, the isolation of the elements, gave us the greatest problem. I just used an ion exchange resin Zeocarb 226 to absorb the ions from the organic mess. This was new in those days. It was so easy but nobody thought of it or dared to try it.
The second part was not a problem. There were sufficient methods including the ones you mentioned, even in those old days to easily determine the amounts of Lead & Copper present.
The third part is the important point I tried to make. If you dare not think out of the box or overcome obstacles in your way, you will be stuck.
Again this is another incident where we can use our Mind, which I believe is a force , to do simple things which can lead to bigger things to come.
Lee Kum Tatt
I do not know too much about QA techniques used here but was there any problem with usuing ETDA chelation + UV-vis spectrophotometry of some sorts? Or were the amounts too small even for that ?
REPLY:
The incident I referred too happened in 1954. The technology was not as sophisticated then as it is now with modern instrumentation. The problem consisted of three parts:
a. the separation of Lead and Copper ions from the unholy organic mixtures in wine and the high sugar content in it for analysis.
b. the quantitative determination of these elements is from 0 to 1.5 parts per million in wine..
c. the strong urge to do something to improve the method then in use and face the consequences to make the change.
The first part, the isolation of the elements, gave us the greatest problem. I just used an ion exchange resin Zeocarb 226 to absorb the ions from the organic mess. This was new in those days. It was so easy but nobody thought of it or dared to try it.
The second part was not a problem. There were sufficient methods including the ones you mentioned, even in those old days to easily determine the amounts of Lead & Copper present.
The third part is the important point I tried to make. If you dare not think out of the box or overcome obstacles in your way, you will be stuck.
Again this is another incident where we can use our Mind, which I believe is a force , to do simple things which can lead to bigger things to come.
Lee Kum Tatt
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